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It would also help explain a clinical observation discussed later: the gastrointestinal side effects associated with amylin analogs (nausea, early fullness) tend to be most pronounced during dose escalation and to ease with continued treatment, a pattern consistent with partial adaptation of the very gastric mechanism in question

Interdiscip Toxicol 5:117122 Tonelli C, Chio IIC, Tuveson DA (2018) Transcriptional regulation by Nrf2

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Follow the recommended dosage instructions on the product label